The new model will be used for evaluating the efficacy and safety of cosmetic ingredients and products.
A newly developed three-dimensional epithelial model that reproduces the human lip area from the oral mucosa to the lips and surrounding skin using cell culture help evaluate the efficacy and safety of cosmetic ingredients and products.
Until now, it has been necessary to use in vitro skin and oral mucosa models to evaluate the usefulness and safety of new ingredients, according to researchers from KOSÉ Corporation in Chuo-ku, Tokyo and Niigata University Graduate School of Medical and Dental Sciences (Faculty of Dentistry) in Niigata, Japan.
The research group developed a lip area model to be used in cosmetics research. They used only cells derived from the epidermis and oral mucosal epithelium to develop a three-dimensional model with characteristics similar to those of the human lip area. The immunohistochemical findings demonstrated that the lip area model has a similar structure and differentiation mode to that of actual human lip area tissue.
The study is published in June 2023 issue of Histochemistry and Cell Biology.
PHOTO CAPTION: TISSUE STAINING OF THE CONSTRUCTED LIP AREA MODEL REVEALED THAT THE CELLS HAVE STRUCTURES AND FEATURES SIMILAR TO ACTUAL SKIN, LIP AREAS, AND ORAL MUCOSA, RESPECTIVELY
